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1

The amyloid state and its association with protein misfolding diseases

Knowles, Tuomas P. J., Vendruscolo, Michele, Dobson, Christopher M.

Journal:

Nature Reviews Molecular Cell Biology

Year:

2014

Language:

english

File:

PDF, 1.45 MB

english, 2014

2

Biomimetic peptide self-assembly for functional materials

Levin, Aviad, Hakala, Tuuli A., Schnaider, Lee, Bernardes, GonÃ§alo J. L., Gazit, Ehud, Knowles, Tuomas P. J.

Journal:

Nature Reviews Chemistry

Year:

2020

File:

PDF, 6.04 MB

2020

3

Chemical Kinetics for Bridging Molecular Mechanisms and Macroscopic Measurements of Amyloid Fibril Formation

Michaels, Thomas C. T., Šarić, Andela, Habchi, Johnny, Chia, Sean, Meisl, Georg, Vendruscolo, Michele, Dobson, Christopher M., Knowles, Tuomas P. J.

Journal:

Annual Review of Physical Chemistry

Year:

2018

Language:

english

File:

PDF, 3.00 MB

english, 2018

4

Detailed Analysis of the Energy Barriers for Amyloid Fibril Growth

Alexander K. Buell, Anne Dhulesia, Duncan A. White, Tuomas P. J. Knowles, Christopher M. Dobson, Mark E. Welland

Journal:

Angewandte Chemie International Edition

Year:

2012

Language:

english

File:

PDF, 1.14 MB

english, 2012

5

Measurement of Amyloid Fibril Length Distributions by Inclusion of Rotational Motion in Solution NMR Diffusion Measurements

Andrew J. Baldwin, Spencer J. Anthony-Cahill, Tuomas P. J. Knowles, Guy Lippens, John Christodoulou, Paul D. Barker, Christopher M. Dobson

Journal:

Angewandte Chemie International Edition

Year:

2008

Language:

english

File:

PDF, 491 KB

english, 2008

6

Reaction rate theory for supramolecular kinetics: application to protein aggregation

Michaels, Thomas C. T., Liu, Lucie X., Curk, Samo, Bolhuis, Peter G., Šarić, Anđela, Knowles, Tuomas P. J.

Journal:

Molecular Physics

Year:

2018

Language:

english

File:

PDF, 2.52 MB

english, 2018

7

Enhancing power density of biophotovoltaics by decoupling storage and power delivery

Saar, Kadi L., Bombelli, Paolo, Lea-Smith, David J., Call, Toby, Aro, Eva-Mari, Müller, Thomas, Howe, Christopher J., Knowles, Tuomas P. J.

Journal:

Year:

2018

Language:

english

File:

PDF, 2.03 MB

english, 2018

8

Latent analysis of unmodified biomolecules and their complexes in solution with attomole detection sensitivity

Yates, Emma V., Müller, Thomas, Rajah, Luke, De Genst, Erwin J., Arosio, Paolo, Linse, Sara, Vendruscolo, Michele, Dobson, Christopher M., Knowles, Tuomas P. J.

Journal:

Nature Chemistry

Year:

2015

Language:

english

File:

PDF, 2.65 MB

english, 2015

9

[Advances in Experimental Medicine and Biology] Biological and Bio-inspired Nanomaterials Volume 1174 (Properties and Assembly Mechanisms) ||

Perrett, Sarah, Buell, Alexander K., Knowles, Tuomas P.J.

Year:

2019

Language:

english

File:

PDF, 12.56 MB

english, 2019

10

Chemical kinetics for drug discovery to combat protein aggregation diseases

Arosio, Paolo, Vendruscolo, Michele, Dobson, Christopher M., Knowles, Tuomas P.J.

Journal:

Trends in Pharmacological Sciences

Year:

2014

Language:

english

File:

PDF, 856 KB

english, 2014

11

Observation of molecular self-assembly events in massively parallel microdroplet arrays

Toprakcioglu, Zenon, Challa, Pavan Kumar, Levin, Aviad, Knowles, Tuomas P. J.

Journal:

Year:

2018

Language:

english

File:

PDF, 30.73 MB

english, 2018

12

Controlling the Physical Dimensions of Peptide Nanotubes by Supramolecular Polymer Coassembly

Adler-Abramovich, Lihi, Marco, Pini, Arnon, Zohar A., Creasey, Rhiannon C. G., Michaels, Thomas C. T., Levin, Aviad, Scurr, David J., Roberts, Clive J., Knowles, Tuomas P. J., Tendler, Saul J. B., Gaz

Journal:

Year:

2016

Language:

english

File:

PDF, 1.88 MB

english, 2016

13

Protein Aggregate-Ligand Binding Assays Based on Microfluidic Diffusional Separation

Zhang, Yingbo, Buell, Alexander K., Müller, Thomas, De Genst, Erwin, Benesch, Justin, Dobson, Christopher M., Knowles, Tuomas P. J.

Journal:

Year:

2016

Language:

english

File:

PDF, 1.68 MB

english, 2016

14

Image-Assisted Microvessel-on-a-Chip Platform for Studying Cancer Cell Transendothelial Migration Dynamics

Bertulli, Cristina, Gerigk, Magda, Piano, Nicholas, Liu, Ye, Zhang, Duo, Müller, Thomas, Knowles, Tuomas J., Huang, Yan Yan Shery

Journal:

Scientific Reports

Year:

2018

Language:

english

File:

PDF, 4.82 MB

english, 2018

15

Nucleation and Growth of Amino-acid and Peptide Supramolecular Polymers through Liquid-liquid Phase Separation

Yan, Xuehai, Yuan, Chengqian, Levin, Aviad, Chen, Wei, Xing, Ruirui, Zou, Qianli, Herling, Therese W., Challa, Pavan Kumar, Knowles, Tuomas P.J.

Journal:

Angewandte Chemie International Edition

Year:

2019

Language:

english

File:

PDF, 929 KB

english, 2019

16

Fluctuations in the Kinetics of Linear Protein Self-Assembly

Michaels, Thomas C. T., Dear, Alexander J., Kirkegaard, Julius B., Saar, Kadi L., Weitz, David A., Knowles, Tuomas P. J.

Journal:

Physical Review Letters

Year:

2016

Language:

english

File:

PDF, 598 KB

english, 2016

17

Microfluidic approaches for probing amyloid assembly and behaviour

Herling, Therese W., Levin, Aviad, Saar, Kadi L., Dobson, Christopher M., Knowles, Tuomas P. J.

Journal:

Year:

2018

Language:

english

File:

PDF, 8.91 MB

english, 2018

18

Statistical Mechanics of Globular Oligomer Formation by Protein Molecules

Dear, Alexander John, Saric, Andela, Michaels, Thomas C.T., Dobson, Christopher M., Knowles, Tuomas P.J.

Journal:

Journal of Physical Chemistry B

Year:

2018

Language:

english

File:

PDF, 716 KB

english, 2018

19

Highly specific label-free protein detection from lysed cells using internally referenced microcantilever sensors

Wenmiao Shu, Sophie Laurenson, Tuomas P.J. Knowles, Paul Ko Ferrigno, Ashwin A. Seshia

Journal:

Biosensors and Bioelectronics

Year:

2008

Language:

english

File:

PDF, 551 KB

english, 2008

20

Multiphase Protein Microgels

Shimanovich, Ulyana, Song, Yang, Brujic, Jasna, Shum, Ho Cheung, Knowles, Tuomas P. J.

Journal:

Macromolecular Bioscience

Year:

2015

Language:

english

File:

PDF, 5.46 MB

english, 2015

21

Crucial role of nonspecific interactions in amyloid nucleation

Šarić, Anđela, Chebaro, Yassmine C., Knowles, Tuomas P. J., Frenkel, Daan

Journal:

Proceedings of the National Academy of Sciences

Year:

2014

Language:

english

File:

PDF, 1.10 MB

english, 2014

22

Microfluidic devices fabricated using fast wafer-scale LED-lithography patterning

Challa, Pavan K., Kartanas, Tadas, Charmet, Jérôme, Knowles, Tuomas P. J.

Journal:

Biomicrofluidics

Year:

2017

Language:

english

File:

PDF, 2.38 MB

english, 2017

23

Twisting Transition between Crystalline and Fibrillar Phases of Aggregated Peptides

Knowles, Tuomas P. J., De Simone, Alfonso, Fitzpatrick, Anthony W., Baldwin, Andrew, Meehan, Sarah, Rajah, Luke, Vendruscolo, Michele, Welland, Mark E., Dobson, Christopher M., Terentjev, Eugene M.

Journal:

Physical Review Letters

Year:

2012

Language:

english

File:

PDF, 580 KB

english, 2012

24

Spatial Persistence of Angular Correlations in Amyloid Fibrils

Knowles, Tuomas P. J., Smith, Jeffrey F., Craig, Aidan, Dobson, Christopher M., Welland, Mark E.

Journal:

Physical Review Letters

Year:

2006

Language:

english

File:

PDF, 1.15 MB

english, 2006

25

The amyloid state and its association with protein misfolding diseases

Knowles, Tuomas P. J., Vendruscolo, Michele, Dobson, Christopher M.

Journal:

Nature Reviews Molecular Cell Biology

Year:

2014

File:

PDF, 516 KB

2014

26

Frequency Factors in a Landscape Model of Filamentous Protein Aggregation

Buell, Alexander K., Blundell, Jamie R., Dobson, Christopher M., Welland, Mark E., Terentjev, Eugene M., Knowles, Tuomas P. J.

Journal:

Physical Review Letters

Year:

2010

Language:

english

File:

PDF, 312 KB

english, 2010

27

Connecting Macroscopic Observables and Microscopic Assembly Events in Amyloid Formation Using Coarse Grained Simulations

Bieler, Noah S., Knowles, Tuomas P. J., Frenkel, Daan, Vácha, Robert, Tajkhorshid, Emad

Journal:

PLoS Computational Biology

Year:

2012

Language:

english

File:

PDF, 1.12 MB

english, 2012

28

Mean-field master equation formalism for biofilament growth

Michaels, Thomas C. T., Knowles, Tuomas P. J.

Journal:

American Journal of Physics

Year:

2014

Language:

english

File:

PDF, 876 KB

english, 2014

29

Effects of sedimentation, microgravity, hydrodynamic mixing and airâwater interface on Î±-synuclein amyloid formation

Zhou, Jiangtao, Ruggeri, Francesco S., Zimmermann, Manuela R., Meisl, Georg, Longo, Giovanni, Sekatskii, Sergey K., Knowles, Tuomas P. J., Dietler, Giovanni

Journal:

Chemical Science

Year:

2020

File:

PDF, 730 KB

2020

30

Physical determinants of the self-replication of protein fibrils

Šarić, Anđela, Buell, Alexander K., Meisl, Georg, Michaels, Thomas C. T., Dobson, Christopher M., Linse, Sara, Knowles, Tuomas P. J., Frenkel, Daan

Journal:

Year:

2016

Language:

english

File:

PDF, 1.08 MB

english, 2016

31

Mechanobiology of Protein Droplets: Force Arises from Disorder

Welsh, Timothy J., Shen, Yi, Levin, Aviad, Knowles, Tuomas P.J.

Journal:

Year:

2018

Language:

english

File:

PDF, 498 KB

english, 2018

32

A High Power-Density, Mediator-Free, Microfluidic Biophotovoltaic Device for Cyanobacterial Cells

Bombelli, Paolo, Müller, Thomas, Herling, Therese W., Howe, Christopher J., Knowles, Tuomas P. J.

Journal:

Advanced Energy Materials

Year:

2015

Language:

english

File:

PDF, 993 KB

english, 2015

33

Kinetics of spontaneous filament nucleation via oligomers: Insights from theory and simulation

Šarić, Anđela, Michaels, Thomas C. T., Zaccone, Alessio, Knowles, Tuomas P. J., Frenkel, Daan

Journal:

The Journal of Chemical Physics

Year:

2016

Language:

english

File:

PDF, 1.21 MB

english, 2016

34

Nanoscale click-reactive scaffolds from peptide self-assembly

Guttenplan, Alexander P. M., Young, Laurence J., Matak-Vinkovic, Dijana, Kaminski, Clemens F., Knowles, Tuomas P. J., Itzhaki, Laura S.

Journal:

Journal of Nanobiotechnology

Year:

2017

Language:

english

File:

PDF, 2.67 MB

english, 2017

35

The physical chemistry of the amyloid phenomenon: thermodynamics and kinetics of filamentous protein aggregation

Buell, Alexander K., Dobson, Christopher M., Knowles, Tuomas P.J.

Journal:

Essays in Biochemistry

Year:

2014

Language:

english

File:

PDF, 1.11 MB

english, 2014

36

Hamiltonian Dynamics of Protein Filament Formation

Michaels, Thomas C. T., Cohen, Samuel I. A., Vendruscolo, Michele, Dobson, Christopher M., Knowles, Tuomas P. J.

Journal:

Physical Review Letters

Year:

2016

Language:

english

File:

PDF, 672 KB

english, 2016

37

Nucleation-conversion-polymerization reactions of biological macromolecules with prenucleation clusters

Garcia, Gonzalo A., Cohen, Samuel I. A., Dobson, Christopher M., Knowles, Tuomas P. J.

Journal:

Physical Review E

Year:

2014

Language:

english

File:

PDF, 805 KB

english, 2014

38

Analysis of the length distribution of amyloid fibrils by centrifugal sedimentation

Arosio, Paolo, Cedervall, Tommy, Knowles, Tuomas P.J., Linse, Sara

Journal:

Analytical Biochemistry

Year:

2016

Language:

english

File:

PDF, 1.41 MB

english, 2016

39

Selenium-Enhanced Electron Microscopic Imaging of Different Aggregate Forms of a Segment of the Amyloid β Peptide in Cells

McGuire, Eva K., Motskin, Michael, Bolognesi, Benedetta, Bergin, Shane D., Knowles, Tuomas P. J., Skepper, Jeremy, Luheshi, Leila M., McComb, David W., Dobson, Christopher M., Porter, Alexandra E.

Journal:

Year:

2012

Language:

english

File:

PDF, 3.56 MB

english, 2012

40

Preventing peptide and protein misbehavior: Fig. 1.

Arosio, Paolo, Meisl, Georg, Andreasen, Maria, Knowles, Tuomas P. J.

Journal:

Proceedings of the National Academy of Sciences

Year:

2015

Language:

english

File:

PDF, 718 KB

english, 2015

41

Quantitative analysis of co-oligomer formation by amyloid-beta peptide isoforms

Iljina, Marija, Garcia, Gonzalo A., Dear, Alexander J., Flint, Jennie, Narayan, Priyanka, Michaels, Thomas C. T., Dobson, Christopher M., Frenkel, Daan, Knowles, Tuomas P. J., Klenerman, David

Journal:

Scientific Reports

Year:

2016

Language:

english

File:

PDF, 776 KB

english, 2016

42

The length distribution of frangible biofilaments

Michaels, Thomas C. T., Yde, Pernille, Willis, Julian C. W., Jensen, Mogens H., Otzen, Daniel, Dobson, Christopher M., Buell, Alexander K., Knowles, Tuomas P. J.

Journal:

The Journal of Chemical Physics

Year:

2015

Language:

english

File:

PDF, 2.51 MB

english, 2015

43

Intra-chain organisation of hydrophobic residues controls inter-chain aggregation rates of amphiphilic polymers

Varilly, Patrick, Willard, Adam P., Kirkegaard, Julius B., Knowles, Tuomas P. J., Chandler, David

Journal:

The Journal of Chemical Physics

Year:

2017

Language:

english

File:

PDF, 2.07 MB

english, 2017

44

Secondary nucleation of monomers on fibril surface dominates α-synuclein aggregation and provides autocatalytic amyloid amplification

Gaspar, Ricardo, Meisl, Georg, Buell, Alexander K., Young, Laurence, Kaminski, Clemens F., Knowles, Tuomas P. J., Sparr, Emma, Linse, Sara

Journal:

Quarterly Reviews of Biophysics

Year:

2017

Language:

english

File:

PDF, 732 KB

english, 2017

45

On-chip label-free protein analysis with downstream electrodes for direct removal of electrolysis products

Saar, Kadi L., Zhang, Yingbo, Müller, Thomas, Kumar, Challa P., Devenish, Sean, Lynn, Andrew, Łapińska, Urszula, Yang, Xiaoting, Linse, Sara, Knowles, Tuomas P. J.

Journal:

Year:

2017

Language:

english

File:

PDF, 3.21 MB

english, 2017

46

Identification of Oxidative Stress in Red Blood Cells with Nanoscale Chemical Resolution by Infrared Nanospectroscopy

Ruggeri, Francesco, Marcott, Curtis, Dinarelli, Simone, Longo, Giovanni, Girasole, Marco, Dietler, Giovanni, Knowles, Tuomas

Journal:

International Journal of Molecular Sciences

Year:

2018

Language:

english

File:

PDF, 3.72 MB

english, 2018

47

A method of predicting the in vitro fibril formation propensity of Aβ40 mutants based on their inclusion body levels in E. coli

Sanagavarapu, Kalyani, Nüske, Elisabeth, Nasir, Irem, Meisl, Georg, Immink, Jasper N., Sormanni, Pietro, Vendruscolo, Michele, Knowles, Tuomas P. J., Malmendal, Anders, Cabaleiro-Lago, Celia, Linse, S

Journal:

Scientific Reports

Year:

2019

File:

PDF, 4.65 MB

2019

48

Characterizing Individual Protein Aggregates by Infrared Nanospectroscopy and Atomic Force Microscopy

Ruggeri, Francesco Simone, Šneideris, Tomas, Chia, Sean, Vendruscolo, Michele, Knowles, Tuomas P. J.

Journal:

Journal of Visualized Experiments

Year:

2019

Language:

english

File:

PDF, 1.17 MB

english, 2019

49

Multi-scale microporous silica microcapsules from gas-in water-in oil emulsions

Toprakcioglu, Zenon, Hakala, Tuuli A., Levin, Aviad, Becker, Christian F. W., Bernandes, GonÃ§alo G. L., Knowles, Tuomas P. J.

Journal:

Year:

2020

File:

PDF, 4.19 MB

2020

50

The Influence of Pathogenic Mutations in Î±-Synuclein on Biophysical and Structural Characteristics of Amyloid Fibrils

Ruggeri, Francesco Simone, Flagmeier, Patrick, Kumita, Janet R., Meisl, Georg, Chirgadze, Dimitri Y., Bongiovanni, Marie N., Knowles, Tuomas P.J., Dobson, Christopher M.

Journal:

Year:

2020

File:

PDF, 2.49 MB

2020

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